Tyrosiinin katabolia: Maleylasetoasetaatti.-isomeraasi GSTZ1(14q24.3), MAA1

https://www.ncbi.nlm.nih.gov/gene/2954

Official Symbol

GSTZ1p

Official Full Name

glutathione S-transferase zeta 1

Also known as

MAI; MAAI; MAAID; GSTZ1-1

Summary

This gene is a member of the glutathione S-transferase (GSTs) super-family which encodes multifunctional enzymes important in the detoxification of electrophilic molecules, including carcinogens, mutagens, and several therapeutic drugs, by conjugation with glutathione. This enzyme catalyzes the conversion of maleylacetoacetate to fumarylacetoacatate, which is one of the steps in the phenylalanine/tyrosine degradation pathway. Deficiency of a similar gene in mouse causes oxidative stress. Several transcript variants of this gene encode multiple protein isoforms. [provided by RefSeq, Jul 2015]

Expression  Broad expression in liver (RPKM 23.8), testis (RPKM 10.9) and 24 other tissues See more  Orthologs mouse all

 

Preferred Names

maleylacetoacetate isomerase

Names

S-(hydroxyalkyl)glutathione lyase

glutathione S-alkyltransferase

glutathione S-aralkyltransferase

glutathione S-aryltransferase

glutathione transferase zeta 1

maleylacetone isomerase

 Features: https://www.ncbi.nlm.nih.gov/protein/NP_001299589.1

Conserved Domains (1) summary

cl25459
Location:1 → 156

GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]

 

  Related articles PubMed

1. Age-Related Changes in Expression and Activity of Human Hepatic Mitochondrial Glutathione Transferase Zeta1. Zhong G, et al. Drug Metab Dispos, 2018 Aug. PMID 29853471,
2. Hypersuccinylacetonaemia and normal liver function in maleylacetoacetate isomerase deficiency. Yang H, et al. J Med Genet, 2017 Apr. PMID 27876694
3. The influence of human GSTZ1 gene haplotype variations on GSTZ1 expression. Langaee TY, et al. Pharmacogenet Genomics, 2015 May. PMID 25738370, Free PMC Article
4. Haplotype variations in glutathione transferase zeta 1 influence the kinetics and dynamics of chronic dichloroacetate in children. Shroads AL, et al. J Clin Pharmacol, 2015 Jan. PMID 25079374, Free PMC Article
5. Glutathione S-transferase Z1 (GSTZ1) gene polymorphism in gastric cancer: a preliminary study in a Turkish population. Karakaş-Celik S, et al. Lab Med, 2014 Winter. PMID 24719983

See all (70) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

1. Some properties of cytosolic and mitochondrial GSTZ1 differed.
2. mild hypersuccinylacetonaemia (MHSA)can be caused by sequence variants in GSTZ1. Such individuals have thus far remained asymptomatic despite receiving no specific treatment.
3. rs7975 GG carriers had an increased risk of below-reference sperm motility
4. We conclude that the lower expression of GSTZ1 in Whites who possess the K carrier haplotype results in lower enzymatic activity and slower metabolism of DCA, compared with those who possess the non-K carrier haplotype
5. Haplotype variations in glutathione transferase zeta 1 influence the kinetics and dynamics of chronic dichloroacetate in children
6. The data indicates no association between GSTZ1 genotypes and risk of gastric cancer.
7. Two SNPs, rs282070 located in intron 1 of the MAP3K7 gene, and rs2111699 located in intron 1 of the GSTZ1 gene, were significantly associated (after adjustment for multiple testing) with longevity in stage 2
8. The ping-pong catalytic mechanism of Se-hGSTZ1-1 is similar to that of the natural GPX.
9. Elucidation of the role of individual residues in the N-terminal, SSC motif of human GSTZ1.
10. This study was performed on 228 BPD patients and 234 control subjects. Among early-onset patients, the variant alleles of Glu32Lys and G-1002A increased BPD susceptibility.