SLC39A9 , Ebolaviruksen tarvitsema sinkinkujettajaproteiini , jota virus käyttää etsiytyessään endosomaalisiiin solunsisäteihin. Onkohan miehet alttiimpia Ebolaviruksille???

https://www.genecards.org/cgi-bin/carddisp.pl?gene=SLC39A9&keywords=SLC39A9

https://pathway-viewer.toolforge.org/embed/WP3529

• GeneCards Symbol: SLC39A9 2 
• Solute Carrier Family 39 Member 9 2 3 4 5
• ZIP9 2 3 4 5
• Zrt- And Irt-Like Protein 9 3 4
• ZRT/IRT-Like Protein 9 2 3
• Zinc Transporter ZIP9 3 4

• Zinc Transporter 9 2 3
• FLJ11274 2 5
• ZIP-9 3 4
• Solute Carrier Family 39 (Zinc Transporter), Member 9 3
• Solute Carrier Family 39, Member 9 2
• Zinc Transporter SLC39A9 
• Enables G protein-coupled receptor activity; androgen binding activity; and zinc efflux transmembrane transporter activity.

Involved in intracellular zinc ion homeostasis; regulation of vascular endothelial cell proliferation; and zinc ion transmembrane transport. 

Located in several cellular components, including mitochondrial membrane; perinuclear region of cytoplasm; and trans-Golgi network. [provided by Alliance of Genome Resources, Jul 2025]

GeneCards Summary for SLC39A9 Gene

SLC39A9 (Solute Carrier Family 39 Member 9) is a Protein Coding gene. Diseases associated with SLC39A9 include Brown-Vialetto-Van Laere Syndrome 2 and Androgen Insensitivity Syndrome. Among its related pathways are Nuclear receptors meta-pathway and Metal ion SLC transporters. Gene Ontology (GO) annotations related to this gene include metal ion transmembrane transporter activity.

UniProtKB/Swiss-Prot Summary for SLC39A9 Gene

Mediates androgen-induced vascular endothelial cell proliferation through activation of an inhibitory G protein leading to the AKT1 and MAPK3/MAPK1 (Erk1/2) activation which in turn modulate inhibition (phosphorylation) of GSK3B and CCND1 transcription (PubMed:34555425). Moreover, has dual functions as a membrane-bound androgen receptor and as an androgen-dependent zinc transporter both of which are mediated through an inhibitory G protein (Gi) that mediates both MAP kinase and zinc signaling leading to the androgen-dependent apoptotic process (PubMed:25014355, 28219737). ( S39A9_HUMAN,Q9NUM3 )

Function:

• Transports zinc ions across cell and organelle membranes into the cytoplasm and regulates intracellular zinc homeostasis (PubMed:19420709, 25014355, 28219737).
  Participates in the zinc ions efflux out of the secretory compartments (PubMed:19420709).
  Regulates intracellular zinc level, resulting in the enhancement of AKT1 and MAPK3/MAPK1 (Erk1/2) phosphorylation in response to the BCR activation (PubMed:23505453).
  Also functions as a membrane androgen receptor that mediates, through a G protein, the non-classical androgen signaling pathway, characterized by the activation of MAPK3/MAPK1 (Erk1/2) and transcription factors CREB1 or ATF1 (By similarity).
  This pathway contributes to CLDN1 and CLDN5 expression and tight junction formation between adjacent Sertoli cells (By similarity).
  Mediates androgen-induced vascular endothelial cell proliferation through activation of an inhibitory G protein leading to the AKT1 and MAPK3/MAPK1 (Erk1/2) activation which in turn modulate inhibition (phosphorylation) of GSK3B and CCND1 transcription (PubMed:34555425).
  Moreover, has dual functions as a membrane-bound androgen receptor and as an androgen-dependent zinc transporter both of which are mediated through an inhibitory G protein (Gi) that mediates both MAP kinase and zinc signaling leading to the androgen-dependent apoptotic process (PubMed:25014355, 28219737). S39A9_HUMAN,Q9NUM3

CatalyticActivity:

• Reaction=Zn(2+)(in) = Zn(2+)(out); Xref=RHEA:29351, CHEBI:29105; Evidence={ECO:0000269 PubMed:19420709, 25014355 | ECO:0000305 PubMed:28219737}. S39A9_HUMAN,Q9NUM3

Induction:

• Up-regulated by testosterone in cancer cells. S39A9_HUMAN,Q9NUM3