PRRG2 (PPXY ja PY motiivin omaava proliinipitoinen VKDP proteiini.

 Tästä proteiini PRGP2 tekstistä käy ilmi, että myös tämä sitoo hyaluronaania ja juuri sen GLA-domeeni toimii hyaluronaania sitovana. Siis  hyaluronaanin sitovuus riippuu  K1-vitamiinistatuksesta.

 

Official Symbol

PRRG2provided by HGNC

Official Full Name

proline rich and Gla domain 2

Also known as

PRGP2

Summary

The protein encoded by this gene is a single-pass transmembrane protein containing an N-terminal gamma-carboxyglutamic acid (Gla) domain and tandem Pro/Leu-Pro-Xaa-Tyr (PY) motifs at its C-terminal end. The Gla domain is exposed on the cell surface while the PY motifs are cytoplasmic. The PY motifs of the encoded protein have been shown to interact with YAP1, a WW domain-containing protein. Therefore, it is thought that the encoded protein may be part of a signal transduction pathway. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]

Expression

Broad expression in duodenum (RPKM 5.0), thyroid (RPKM 4.3) and 18 other tissues See more

Orthologs

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Preferred Names

transmembrane gamma-carboxyglutamic acid protein 2

Names

proline rich Gla (G-carboxyglutamic acid) 2

proline-rich Gla (G-carboxglutamic acid) polypeptide 2

proline-rich Gla (G-carboxyglutamic acid) polypeptide 2

proline-rich Gla protein 2

proline-rich gamma-carboxyglutamic acid protein 2

Conserved Domains (2) summary

cd12087
Location:109 → 138

TM_EGFR-like; Transmembrane domain of the Epidermal Growth Factor Receptor family of Protein Tyrosine Kinases PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. EGFR (HER, ErbB) subfamily members include EGFR (HER1, ErbB1), HER2 (ErbB2), HER3 (ErbB3), HER4 (ErbB4), and similar proteins. They are receptor PTKs (RTKs) containing an extracellular EGF-related ligand-binding region, a transmembrane (TM) helix, and a cytoplasmic region with a tyr kinase domain and a regulatory C-terminal tail. They are activated by ligand-induced dimerization, resulting in the phosphorylation of tyr residues in the C-terminal tail, which serve as binding sites for downstream signaling molecules. Collectively, they can recognize a variety of ligands including EGF, TGFalpha, and neuregulins, among others. All four subfamily members can form homo- or heterodimers. HER3 contains an impaired kinase domain and depends on its heterodimerization partner for activation. EGFR subfamily members are involved in signaling pathways leading to a broad range of cellular responses including cell proliferation, differentiation, migration, growth inhibition, and apoptosis. The TM domain not only serves as a membrane anchor, but also plays an important role in receptor dimerization and optimal activation. Mutations in the TM domain of EGFR family RTKs have been associated with increased breast cancer risk.

smart00069
Location:28 → 95

GLA; Domain containing Gla (gamma-carboxyglutamate) residues

A hyaluronan-binding domain found in proteins associated with the extracellular matrix, cell adhesion and cell migration.