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tisdag 7 juli 2020

31 tRNA lajia, transferRNA

 https://www.researchgate.net/publication/323460875/figure/fig2/AS:599174114447363@1519865649894/Transfer-RNA-structure-and-biogenesis-of-transfer-RNA-fragments-tRFs-The-cloverleaf.png
 https://www.researchgate.net/publication/323460875/figure/fig2/AS:599174114447363@1519865649894/Transfer-RNA-structure-and-biogenesis-of-transfer-RNA-fragments-tRFs-The-cloverleaf.png

https://www.sciencedirect.com/sdfe/pdf/download/eid/3-s2.0-B9780323074469000179/first-page-pdf
Protein Synthesis andDegradation
 17CONTENTS 
THE GENETIC CODE
Transfer RNA Adaptor Function *
Aminoacyl-tRNA Synthetases 
Aminoacyl-tRNA Synthetase Proofreading 
Wobble in Anticodon Base-Pairing



*Transfer RNA Adaptor Function
 The 31 species of transfer RNA (tRNA) differ from each other in two important respects. 
The most obvious difference is in the different anticodon sequences that match the attached amino acid to the proper codons in mRNA. 
They also differ in their ability to be recognized by a unique aminoacyl-tRNAsynthetase that matches the amino acid to the codon. 
 All tRNAs have the following common features (see Fig. 16-1):l 

Acceptor arm: The CCA 30-hydroxyl terminus is the site for amino acid attachment.
 It is not specified in the tRNA gene but is added as a post transcriptional modification.l 

Anticodon loop: This part of the tRNA contains a triplet of bases that pair with the mRNA codon in standard antiparallel orientation.l

 D arm: This part of the tRNA is involved in recognition by the proper aminoacyl-tRNA synthetase. The fidelity of translation of the genetic code is totally dependent on the simultaneous recognition of an amino acid and its corresponding tRNA. This arm is named for its dihydrouracil content.l 

TcC arm: This part of the tRNA is involved in a functional binding to the ribosome. It is named for thymine and pseudouracil bases.
 

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