Aminohapoista, peptideistä, proteiineista : Miten ACE2 litityy aminohappojen kuljetukseen?

Yllätyksekseni havaitsin että ACE2 osallistuu myös aminohappojen kuljetukseen - sen lisäksi että sitä maintiaan SARS CoV reseptoriksi. Tänään 14.3. 2020 etsin tästä aiheesta enemmän- nimittäin aminohappojen kuljetukseen osallistumisesta. Seulon näitä 18 löytöä tässä: n huomioon että Sars CoV viruksella on erittäin pitkä suora yksiosainen (+) RNA genomi lähes 30 000 nukleotidia ja siitä siten tgranslatoituna monia työkaluproteiineja ja rakenneproteiinia subgenomisista partikkelista, sen aminohappotarve on todella valtava ja loogista on että se on kiinnostunut niistä solutekijöistä, jotka avustavat sen aminohappoaltaseen pääsy ja aminohappojen saantia replikatioon.
tästä voi sitten jatkaa ja seuloa tätä löytölistaa. DOI 10.1007/s00726-014-1889-6

Best matches for ACE2 , aminoacid transport:

Transport of amino acids in the kidney. Makrides V et al. Compr Physiol. (2014)

Abstract

Amino acids are the building blocks of proteins and key intermediates in the synthesis of biologically important molecules, as well as energy sources, neurotransmitters, regulators of cellular metabolism, etc. The efficient recovery of amino acids from the primary filtrate is a well-conserved key role of the kidney proximal tubule. Additionally, renal metabolism participates in the whole body disposition of amino acids. Therefore, a wide array of axially heterogeneously expressed transporters is localized on both epithelial membranes. For transepithelial transport, luminal uptake, which is carried out mainly by active symporters, is coupled with a mostly passive basolateral efflux. Many transporters require partner proteins for appropriate localization, or to modulate transporter activity, and/or increase substrate supply. Interacting proteins include cell surface antigens

CD98 https://www.ncbi.nlm.nih.gov/gene?cmd=retrieve&dopt=default&list_uids=6520&rn=1 ),
endoplasmic reticulum proteins (GTRAP3-18 or 41), or
enzymes (ACE2 and aminopeptidase N, APN https://www.ncbi.nlm.nih.gov/pubmed/29618640).

In the past two decades, the molecular identification of transporters has led to significant advances in our understanding of amino acid transport and aminoacidurias arising from defects in renal transport. Furthermore, the three-dimensional crystal structures of bacterial homologues have been used to yield new insights on the structure and function of mammalian transporters. Additionally, transgenic animal models have contributed to our understanding of the role of amino acid transporters in the kidney and other organs and/or at critical developmental stages. Progress in elucidation of the renal contribution to systemic amino acid homeostasis requires further integration of kinetic, regulatory, and expression data of amino acid transporters into our understanding of physiological regulatory networks controlling metabolism.

PMID:: 24692143
DOI:: 10.1002/cphy.c130028

ACE2 in Brain Physiology and Pathophysiology: Evidence from Transgenic Animal Models. Alenina N et al. Neurochem Res. (2019)

Expression and regulation of the neutral amino acid transporter B0AT1 in rat small intestine. Jando J et al. PLoS One. (2017)

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Items: 18

Select item 296847191.

Interhelical interactions between D92 and C218 in the cytoplasmic domain regulate proton uptake upon N-decay in the proton transport of Acetabularia rhodopsin II.

Tamogami J, Kikukawa T, Ohkawa K, Ohsawa N, Nara T, Demura M, Miyauchi S, Kimura-Someya T, Shirouzu M, Yokoyama S, Shimono K, Kamo N.

J Photochem Photobiol B. 2018 Jun;183:35-45. doi: 10.1016/j.jphotobiol.2018.04.012. Epub 2018 Apr 11.

PMID:: 29684719

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Miten ACE2 litityy aminohappojen kuljetukseen?

Best matches for ACE2 , aminoacid transport:

Abstract

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Items: 18

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