PDIA6 geeni ja sen koodaama proteiini kliinisista näkökohdista

https://www.genecards.org/cgi-bin/carddisp.pl?gene=PDIA6&keywords=PDIA6 

 

• Symbol: PDIA6

Publications (5/23) See All

• PDIA6 modulates apoptosis and autophagy of non-small cell...signaling pathway. (PMID: 30922965)
  Abstract:

  ...isomerase family 6 (PDIA6) is upregulated in lung squamous cell carcinoma (LSCC)...biological functions, and molecular mechanisms of PDIA6 in NSCLC. The expression of PDIA6 in NSCLC was assessed using the TCGA database, western...blotting, and immunohistochemistry. Correlations of PDIA6 expression with clinicopathological and survival features were evaluated. The functions of PDIA6 in regulating NSCLC cell growth, apoptosis, and autophagy...or in vivo. The underlying molecular mechanisms of PDIA6 function were examined by human phospho-kinase array and co-immunoprecipitation. PDIA6 expression was upregulated in NSCLC compared with adjacent normal tissues, and the higher PDIA6 expression was correlated with poor prognosis. PDIA6 knockdown decreased NSCLC cell proliferation and increased cisplatin-induced intri...
• PDIA6 promotes pancreatic cancer progression and immune...β-catenin and PD-L1. (PMID: 34325342)
  Abstract:

  ...A Member 6 (PDIA6) is an endoplasmic reticulum protein that is capable...bond formation. Abnormally elevated expression of PDIA6 has been reported to predict poor outcomes in various...loss-of-function experiments were performed to investigate how PDIA6 participated in the carcinogenesis of pancreatic cancer (PC). By analyzing the protein expression of PDIA6 in 28 paired PC and para carcinoma specimens, we first found that PDIA6 expression was higher in PC samples. Both the overall...disease-free survival rates of PC patients with higher PDIA6 expression were poorer than those with lower PDIA6 (n = 178). Furthermore, knockdown of PDIA6 impaired the malignancies of PC cells - suppressed...cisplatin resistance, and xenografted tumor growth. PDIA6-silenced PC cells were more sensitive to cytotoxic natur...
• The SOX2/PDIA6 axis mediates aerobic glycolysis to promote stemness...cancer cells. (PMID: 38441855)
  Abstract:

  ...knockdown of PDIA6 expression can predict poor prognosis in various cancers...study aimed to investigate the biological function of PDIA6 in NSCLC. SOX2 and PDIA6 expression in NSCLC tissues and regulatory relationship... GSEA was performed on the enrichment pathway of PDIA6. qRT-PCR was utilized to examine expression of SOX2 and PDIA6 in NSCLC tissues and cells, and dual-luciferase reporter...levels and glycolysis products. High expression of PDIA6 in NSCLC was linked to aerobic glycolysis. Knockdown of PDIA6 reduced ce...
• Protein disulfide isomerase family 6 promotes...Wnt3a-Frizzled1 axis. (PMID: 34781823)
  Abstract:

  ...isomerase family 6 (PDIA6) was involved in the chemo-resistance of lung adenocarcinoma. In this study, the effect of PDIA6 on imatinib-resistance of renal cell carcinoma was investigated. First, PDIA6 was found to be up-regulated in the imatinib-resistant...cells. Functional assays showed that knockdown of PDIA6 sensitized imatinib-resistant renal cell carcinoma...imatinib-resistant renal cell carcinoma cells was suppressed by PDIA6 silencing, and the apoptosis was promoted with reduced...cleaved caspase-3. Moreover, the interference of PDIA6 increased phosphorylation of H2A histone family member...(p-DNA-PK) in imatinib-resistant renal cell carcinoma...
• The Inhibitory Effect of PDIA6 Downregulation on Bladder Cancer Cell Proliferation...and Invasion. (PMID: 27760590)
  Abstract:

  Protein disulfide isomerases A6 (PDIA6) belongs to the PDI family. Recently, PDIA6 was found to have a close association with various...little investigation into the biological functions of PDIA6 in bladder cancer (BC). In this study, we explored...expression pattern and functional significance of PDIA6 in BC. We found that PDIA6 was overexpressed in BC tissues and cell lines. The in vitro study showed that PDIA6 downregulation significantly inhibited BC proliferation...addition, the in vivo experiment demonstrated that PDIA6 downregulation decreased the volume, weight, and metastasis of tumors. Furthermore, PDIA6 downregulation reduced the protein expression of β-catenin...signaling pathway. In conclusion, we suggest that PDIA6 could be targeted for the treatment of BC.