Tapasin uuden ZFP36 sinkkiproteiini, tritetrapoliinin.

 ZFP36 

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1

The microRNA-29ab1/Zfp36/AR Axis in the Hypothalamus Regulates Male-Typical Behaviors in Mice.

Ma J, Lin Y, Xiong W, Liu X, Pan M, Sun J, Sun Y, Li Y, Guo H, Pang G, Wang X, Ren F. Int J Mol Sci. 2024 Dec 5;25(23):13089. doi: 10.3390/ijms252313089. PMID: 39684798 Free PMC article.

Using bioinformatics analysis and dual-luciferase reporter assays, we identified zinc finger protein 36 (Zfp36) as a direct downstream target gene of miR-29ab1. We subsequently showed that ZFP36 colocalized with AR in GT1-7 cells. Furthermore, inhibition of Zfp36 …

2

Integrative bioinformatics analysis reveals novel insights into osteoarthritis pathogenesis and diagnostic biomarkers.

Chen Q, Li X, Li P, Liu H, Zhang Q, He L, Tang Z, Song H. BMC Musculoskelet Disord. 2024 Dec 5;25(1):999. doi: 10.1186/s12891-024-08124-3. PMID: 39639239 Free PMC article.

Fifteen core lipopolysaccharide-related genes (LRGs) were found, enriched in immune and inflammatory pathways. Three hub genes (CCL3, ZFP36, and CCN1) emerged as potential biomarkers for OA diagnosis, with a nomogram showing high predictive accuracy, and validated by using …

3

Integrated explainable machine learning and multi-omics analysis for survival prediction in cancer with immunotherapy response.

Hounye AH, Xiong L, Hou M. Apoptosis. 2024 Dec 4. doi: 10.1007/s10495-024-02050-4. Online ahead of print. PMID: 39633110

To explicitly clarify the model's decision-making process and uncover novel findings, an interpretable technique incorporating machine learning and SHapley Additive exPlanations (SHAP), as well as LIME, has been employed, and four genes EPGN, PHF11, RBM34, and ZFP36 were i …

4

Transcriptomic and Metabolomic Insights into Age-Related Changes in Lung Tissue of Yaks Under Highland Stress.

Cui C, Chen S, Mi B, Qi Y, Jiao C, Zhang M, Dai Y, Wang X, Hu J, Shi B, Wang J, Zhao Z, Liu X, Zhang X. Int J Mol Sci. 2024 Nov 10;25(22):12071. doi: 10.3390/ijms252212071. PMID: 39596139 Free PMC article.

In addition, some critical differentially expressed genes related to angiogenesis (MYC, EPHA2, TNF), fiber formation (EREG), smooth muscle proliferation (HBEGF), erythropoiesis (SOCS3), and hypoxia response (ZFP36) were identified. Some metabolites associated with these ge …

5

ZFP36 Regulates Vascular Smooth Muscle Contraction and Maintains Blood Pressure.

Cui X, Wang Y, Lu H, Wang L, Xie X, Zhang S, Kovarik P, Li S, Liu S, Zhang Q, Yang J, Zhang C, Tian J, Liu Y, Zhang W. Adv Sci (Weinh). 2024 Nov 26:e2408811. doi: 10.1002/advs.202408811. Online ahead of print. PMID: 39589932

AAV-mediated ZFP36 knockdown ameliorates spontaneous hypertension in rats. These findings elucidate that ZFP36 plays an important role in the regulation of smooth muscle contraction and blood pressure through modulating RGS2 expression. ZFP36 inhibition may r …

6

Low tristetraprolin expression activates phenotypic plasticity and primes transition to lethal prostate cancer in mice.

Morel KL, Germán B, Hamid AA, Nanda JS, Linder S, Bergman AM, van der Poel H, Hofland I, Bekers EM, Trostel SY, Burkhart DL, Wilkinson S, Ku AT, Kim M, Kim J, Ma D, Plummer JT, You S, Su XA, Zwart W, Sowalsky AG, Sweeney CJ, Ellis L. J Clin Invest. 2024 Nov 19:e175680. doi: 10.1172/JCI175680. Online ahead of print. PMID: 39560993 Free article.

We also examined the clinical and biological impact of ZFP36 loss with co-loss of PTEN, a known driver of PCa. Analysis of multiple independent primary PCa cohorts demonstrated that PTEN and ZFP36 co-loss was associated with increased recurrence risk. ...Zfp36 …

7

Identifying a CD8T cell signature in the tumor microenvironment to forecast gastric cancer outcomes from sequencing data.

Zeng X, Shapaer T, Tian J, Abudoukelimu A, Zhao Z, Shayimu P, Ma B. J Gastrointest Oncol. 2024 Oct 31;15(5):2067-2078. doi: 10.21037/jgo-24-603. Epub 2024 Oct 25. PMID: 39554559 Free PMC article.

Combined with univariate Cox analysis, we ultimately identified 23 CD8T cell-related prognostic genes: TCIM, AADAC, SLC2A3, ZNF331, TSC22D3, CMTM3, ZFP36, VIM, CLDND1, GABARAPL1, SOCS3, RGS1, TCEAL9, RGS2, CD59, SPRY1, EMP3, ZEB2, PDE4B, GLIPR1, ERRFI1, and LBH. ...

8

ZFP36 Facilitates Senecavirus A (SVA) replication by inhibiting the production of type I interferon.

Yin M, Guan L, Zhang M, Li X, Qian P. Virus Res. 2024 Dec;350:199498. doi: 10.1016/j.virusres.2024.199498. Epub 2024 Nov 18. PMID: 39547416 Free article.

Overexpression of ZFP36 facilitated Senecavirus A infection, while hZFP36 knockdown inhibited viral replication. ...These findings provide insights into the mechanism of action of ZFP36 in host-virus interactions....

9

ZFP36, an RNA-binding protein promotes hBMSCs osteogenic differentiation via binding with JUN.

Su H, Liang L, Wang J, Yuan X, Zhao B. J Orthop Surg Res. 2024 Nov 14;19(1):758. doi: 10.1186/s13018-024-05232-7. PMID: 39543732 Free PMC article.

Bioinformatics prediction indicates that ZFP36 ring finger protein (ZFP36), an RNA-binding protein, is a potential target of OP. Herein, we sought to probe the regulatory role and mechanisms of ZFP36 in the progression of OP. Overexpression of ZFP36 en …

10

Glabridin inhibits proliferation and migration in hepatocellular carcinoma by regulating multi-targets.

Wang F, Yuan C, Lu Y, Wu M, Wu H, Liu Y, Yang Y. J Ethnopharmacol. 2025 Feb 10;338(Pt 1):119022. doi: 10.1016/j.jep.2024.119022. Epub 2024 Nov 6. PMID: 39510424

Integration of RNA-seq data with clinical databases revealed that Gla inhibited HCC by up-regulating the expression levels of DUSP5, ZFP36, KLF10, and NR4A1, while down-regulating RMI2 expression. These findings were further validated by Gene Expression Omnibus (GEO), qPCR …