CD204 alias SCARA1, Makrofagin scavenger reseptori A1

 https://www.genecards.org/cgi-bin/carddisp.pl?gene=MSR1

Aliases for MSR1 Gene

• GeneCards Symbol: MSR1 2 
• Macrophage Scavenger Receptor 1 2 3 5
• SCARA1 2 3 4 5
• SR-AIII 2 3 5
• SR-AII 2 3 5
• CD204 2 3 5
• SR-AI 2 3 5
• SR-A 2 3 5

• Macrophage Scavenger Receptor Types I And II 3 4
• Macrophage Acetylated LDL Receptor I And II 3 4
• Scavenger Receptor Class A Member 1 3 4
• Macrophage Scavenger Receptor Type III 3
• CD204 Antigen 4
• PhSR1 3
• PhSR2 3
• SRA 

• This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. [provided by RefSeq, Jul 2008]

GeneCards Summary for MSR1 Gene

MSR1 (Macrophage Scavenger Receptor 1) is a Protein Coding gene. Diseases associated with MSR1 include Barrett Esophagus and Prostate Cancer. Among its related pathways are Binding and Uptake of Ligands by Scavenger Receptors and Vesicle-mediated transport. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and scavenger receptor activity. An important paralog of this gene is SCARA5.

UniProtKB/Swiss-Prot Summary for MSR1 Gene

Membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the en