Treoniinia koskevaa. TARS on treonyyli- tRNA- syntetaasin geeni

Muistiin 5.6. 2017

3. Treoniinia koskevaa

TARS Kr. 5p13.8

TARS2 Kr. 1Q21.2 , mitokondriaalinen

Pseudogeeni Kr. 4.

TARSL2 Kr. 15q26.3.

• TARS threonyl-tRNA synthetase [ Homo sapiens (human) ]

Gene ID: 6897, updated on 4-Jun-2017

Summary

Official Symbol

TARSprovided by HGNC

Official Full Name

threonyl-tRNA synthetaseprovided by HGNC

Primary source

HGNC:HGNC:11572

See related

Ensembl:ENSG00000113407 MIM:187790; Vega:OTTHUMG00000090683

Gene type

protein coding

RefSeq status

REVIEWED

Organism

Homo sapiens

Lineage

Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo

Also known as

ThrRS

Summary

Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Threonyl-tRNA synthetase belongs to the class-II aminoacyl-tRNA synthetase family [provided by RefSeq, Jul 2008]

Orthologs

mouse all

Related articles in PubMed

1. Threonyl-tRNA synthetase overexpression correlates with angiogenic markers and progression of human ovarian cancer. Wellman TL, et al. BMC Cancer, 2014 Aug 27. PMID 25163878, Free PMC Article
2. Secreted Threonyl-tRNA synthetase stimulates endothelial cell migration and angiogenesis. Williams TF, et al. Sci Rep, 2013. PMID 23425968, Free PMC Article
3. Clinical manifestations and outcome of anti-PL7 positive patients with antisynthetase syndrome. Marie I, et al. Eur J Intern Med, 2013 Jul. PMID 23375620
4. Kinetic mechanism of threonyl-tRNA synthetase from human placenta. Pan F, et al. Int J Pept Protein Res, 1982 Aug. PMID 7118437
5. Purification and subunit structure studies of human placental threonyl-tRNA synthetase. Pan F, et al. Int J Pept Protein Res, 1982 Mar. PMID 7118399
   

See all (45) citations in PubMed
See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

1. Results show that TARS expression is increased in epithelial ovarian cancer.
2. Our series mainly underscores that interstitial lung disease is frequent in anti-PL7(tars antibody)patients, leading to high morbidity.
3. A previously undiscovered function for TARS as an angiogenic, pro-migratory extracellular signaling molecule.
   

• TARSL2 threonyl-tRNA synthetase like 2 [ Homo sapiens (human) ]

Gene ID: 123283, updated on 4-Jun-2017

Summary

Official Symbol

TARSL2provided by HGNC

Official Full Name

threonyl-tRNA synthetase like 2provided by HGNC

Primary source

HGNC:HGNC:24728

See related

Ensembl:ENSG00000185418 Vega:OTTHUMG00000149869

Gene type

protein coding

RefSeq status

VALIDATED

Organism

Homo sapiens

Lineage

Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo

Related articles in PubMed

1. Reinvestigation of aminoacyl-tRNA synthetase core complex by affinity purification-mass spectrometry reveals TARSL2 as a potential member of the complex. Kim K, et al. PLoS One, 2013. PMID 24312579, Free PMC Article
2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614, Free PMC Article
3. Panorama of ancient metazoan macromolecular complexes. Wan C, et al. Nature, 2015 Sep 17. PMID 26344197, Free PMC Article
4. A proteome-scale map of the human interactome network. Rolland T, et al. Cell, 2014 Nov 20. PMID 25416956, Free PMC Article
5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Hein MY, et al. Cell, 2015 Oct 22. PMID 26496610
   

See all (10) citations in PubMed
See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

1. TARSL2 is potentially a new component of aminoacyl-tRNA synthetase core-complex
2. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
   

(TARS2 oletettu mitokondriaalinen)

• TARS2 threonyl-tRNA synthetase 2, mitochondrial (putative) [ Homo sapiens (human) ]

Gene ID: 80222, updated on 8-Jun-2017

Summary

Official Symbol

TARS2provided by HGNC

Official Full Name

threonyl-tRNA synthetase 2, mitochondrial (putative)provided by HGNC

Primary source

HGNC:HGNC:30740

See related

Ensembl:ENSG00000143374 MIM:612805; Vega:OTTHUMG00000012809

Gene type

protein coding

RefSeq status

REVIEWED

Organism

Homo sapiens

Lineage

Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo

Also known as

thrRS; TARSL1; COXPD21

Summary

This gene encodes a member of the class-II aminoacyl-tRNA synthetase family. The encoded protein is a mitochondrial aminoacyl-tRNA synthetase. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 4. [provided by RefSeq, Dec 2012]

Orthologs

mouse all

Related articles in PubMed

1. A Human Disease-causing Point Mutation in Mitochondrial Threonyl-tRNA Synthetase Induces Both Structural and Functional Defects. Wang Y, et al. J Biol Chem, 2016 Mar 18. PMID 26811336, Free PMC Article
2. VARS2 and TARS2 mutations in patients with mitochondrial encephalomyopathies. Diodato D, et al. Hum Mutat, 2014 Aug. PMID 24827421, Free PMC Article
3. Genetic association analysis of 13 nuclear-encoded mitochondrial candidate genes with type II diabetes mellitus: the DAMAGE study. Reiling E, et al. Eur J Hum Genet, 2009 Aug. PMID 19209188, Free PMC Article
4. Toward the full set of human mitochondrial aminoacyl-tRNA synthetases: characterization of AspRS and TyrRS. Bonnefond L, et al. Biochemistry, 2005 Mar 29. PMID 15779907
5. A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome. Richter R, et al. EMBO J, 2010 Mar 17. PMID 20186120, Free PMC Article
   

See all (21) citations in PubMed
See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

1. Identification of a TARS2 splicing variant in several human cell lines, which encodes a hmtThrRS derivative lacking a peptide covering a portion of both the editing and the aminoacylation domains.
2. TARS2 mutations caused fatal mitochondrial encephalomyopathy in two siblings.
3. Observational study of gene-disease association. (HuGE Navigator)
4. Meta-analysis of gene-disease association. (HuGE Navigator)
   

Muis 5,7, 2017 tiin entsyymistä, joka etsii ja liittää  treoniinin  sen omalle  tRNA:lle.