EGLN2 , Estrogen-induced Tag6 , Recommended name: Prolyl hydroxylase EGLN2

 

Aliases for EGLN2 Gene, 19q13.2

• GeneCards Symbol: EGLN2 ²
• Egl-9 Family Hypoxia Inducible Factor 2 ^{2 3 5}
• PHD1 ^{2 3 4 5}
• HIFPH1 ^{2 3 5}
• Prolyl Hydroxylase Domain-Containing Protein 1 ^{3 4}
• Hypoxia-Inducible Factor Prolyl Hydroxylase 1 ^{3 4}
• Prolyl Hydroxylase EGLN2 ^{3 4}
• HIF-Prolyl Hydroxylase 1 ^{3 4}
• Estrogen-Induced Tag 6 ^{3 4}
•  ^{https://pubmed.ncbi.nlm.nih.gov/11850811/}
• Egl Nine Homolog 2 ^{3 4}

• HIF-PH1 ^{3 4}
• EIT-6 ^{3 4}
• HPH-1 ^{3 4}
• HPH-3 ^{3 4}
• EIT6 ^{3 4}
• Egl Nine Homolog 2 (C. Elegans) ²
• HIF Prolyl Hydroxylase 1 ²
• EC 1.14.11.29 ⁴
• EC 1.14.11.- ⁴
• EC 1.14.11 ⁴⁷
•  Prolyl hydroxylase that mediates hydroxylation of proline residues in target proteins, such as ATF4, IKBKB, CEP192 and HIF1A (PubMed:11595184, 12039559, 15925519, 16509823, 17114296, 23932902). Target proteins are preferentially recognized via a LXXLAP motif (PubMed:11595184, 12039559, 15925519). Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins (PubMed:11595184, 12039559, 12181324, 15925519, 19339211). Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A (PubMed:11595184, 12039559, 12181324, 15925519). Also hydroxylates HIF2A (PubMed:11595184, 12039559, 15925519). Has a preference for the CODD site for both HIF1A and HIF2A (PubMed:11595184, 12039559, 15925519). Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex (PubMed:11595184, 12039559, 15925519). Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes (PubMed:11595184, 12039559, 15925519). EGLN2 is involved in regulating hypoxia tolerance and apoptosis in cardiac and skeletal muscle (PubMed:11595184, 12039559, 15925519). Also regulates susceptibility to normoxic oxidative neuronal death (PubMed:11595184, 12039559, 15925519). Links oxygen sensing to cell cycle and primary cilia formation by hydroxylating the critical centrosome component CEP192 which promotes its ubiquitination and subsequent proteasomal degradation (PubMed:23932902). Hydroxylates IKBKB, mediating NF-kappa-B activation in hypoxic conditions (PubMed:17114296). Also mediates hydroxylation of ATF4, leading to decreased protein stability of ATF4 (By similarity). ( EGLN2_HUMAN,Q96KS0 )