GeneCards
https://www.genecards.org/cgi-bin/carddisp.pl?gene=ROCK1&keywords=ROCK
Aliases for ROCK1 Gene
External Ids for ROCK1 Gene
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This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. A pseudogene, related to this gene, is also located on chromosome 18. [provided by RefSeq, Aug 2015]
GeneCards Summary for ROCK1 Gene
ROCK1 (Rho Associated Coiled-Coil Containing Protein Kinase 1) is a Protein Coding gene. Diseases associated with ROCK1 include Osteogenic Sarcoma and Omphalocele. Among its related pathways are Semaphorin interactions and Activation of cAMP-Dependent PKA. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is ROCK2.
UniProtKB/Swiss-Prot Summary for ROCK1 Gene
Protein kinase which is a key regulator of the actin cytoskeleton and cell polarity (PubMed:10436159, 10652353, 11018042, 11283607, 17158456, 18573880, 19131646, 8617235, 9722579). Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A (PubMed:10436159, 10652353, 11018042, 11283607, 17158456, 18573880, 19131646, 23093407, 23355470, 8617235, 9722579). Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing (PubMed:18694941). Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress (PubMed:19036714). Acts as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability (By similarity). Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation (PubMed:19181962). Required for centrosome positioning and centrosome-dependent exit from mitosis (By similarity). Plays a role in terminal erythroid differentiation (PubMed:21072057). Inhibits podocyte motility via regulation of actin cytoskeletal dynamics and phosphorylation of CFL1 (By similarity). Promotes keratinocyte terminal differentiation (PubMed:19997641). Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization (By similarity). May regulate closure of the eyelids and ventral body wall by inducing the assembly of actomyosin bundles (By similarity). ( ROCK1_HUMAN,Q13464 )
Molecular function for ROCK1 Gene according to UniProtKB/Swiss-Prot
- Function:
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Protein kinase which is a key regulator of the actin cytoskeleton and cell polarity (PubMed:10436159, 10652353, 11018042, 11283607, 17158456, 18573880, 19131646, 8617235, 9722579).
Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A (PubMed:10436159, 10652353, 11018042, 11283607, 17158456, 18573880, 19131646, 23093407, 23355470, 8617235, 9722579).
Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing (PubMed:18694941).
Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress (PubMed:19036714).
Acts as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability (By similarity).
Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation (PubMed:19181962).
Required for centrosome positioning and centrosome-dependent exit from mitosis (By similarity).
Plays a role in terminal erythroid differentiation (PubMed:21072057).
Inhibits podocyte motility via regulation of actin cytoskeletal dynamics and phosphorylation of CFL1 (By similarity).
Promotes keratinocyte terminal differentiation (PubMed:19997641).
Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization (By similarity).
May regulate closure of the eyelids and ventral body wall by inducing the assembly of actomyosin bundles (By similarity). ROCK1_HUMAN,Q13464
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Protein kinase which is a key regulator of the actin cytoskeleton and cell polarity (PubMed:10436159, 10652353, 11018042, 11283607, 17158456, 18573880, 19131646, 8617235, 9722579).
- CatalyticActivity:
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- Reaction=L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+); Xref=RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, CHEBI:15378, CHEBI:29999, CHEBI:30616, CHEBI:83421, CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000269 PubMed:10436159, 10652353, 11018042, 23093407, 23355470}. ROCK1_HUMAN,Q13464
- Reaction=L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+); Xref=RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, CHEBI:15378, CHEBI:30013, CHEBI:30616, CHEBI:61977, CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000269 PubMed:10436159, 10652353, 11018042, 23093407, 23355470}. ROCK1_HUMAN,Q13464
Subcellular locations from UniProtKB/Swiss-Prot for ROCK1 Gene
- Protein: ROCK1_HUMAN
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- Cytoplasm {ECO:0000269 PubMed:8617235}
- Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250 UniProtKB:P70335}
- Golgi apparatus membrane; Peripheral membrane protein {ECO:0000269 PubMed:12773565}
- Cell projection, bleb {ECO:0000269 PubMed:18694941}
- Cytoplasm, cytoskeleton {ECO:0000250 UniProtKB:P70335}
- Cell membrane {ECO:0000250 UniProtKB:P70335}
- Cell projection, lamellipodium {ECO:0000250 UniProtKB:P70335}
- Cell projection, ruffle {ECO:0000250 UniProtKB:P70335}
- Note: A small proportion is associated with Golgi membranes (PubMed:12773565). Associated with the mother centriole and an intercentriolar linker (By similarity). Colocalizes with ITGB1BP1 and ITGB1 at the cell membrane predominantly in lamellipodia and membrane ruffles, but also in retraction fibers (By similarity). Localizes at the cell membrane in an ITGB1BP1-dependent manner (By similarity) {ECO:0000250 UniProtKB:P70335 | ECO:0000269 PubMed:12773565}
https://compartments.jensenlab.org/Entity?figures=subcell_cell_%%&knowledge=10&textmining=10&predictions=10&type1=9606&type2=-22&id1=ENSP00000382697'
Jatkotekstiä 31.7. 2025. Pohdin ROCK1 ja rOCK2 funktionaalisia eroavuuksia.
- Eroja ROCK 1 ja ROCK2 kesken:
https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2015.00276/full
Koska ROCK1 vaikutata osteoblastien mineralisoitumiseen, kysyn AI:lta ROCK1, ROCK2, Calcium suhteita ja tästä saan viiteen PNA artikkeliin: Vain ROCK1 osallistuu Kalsiumin käsittelyyn.
https://www.pnas.org/doi/10.1073/pnas.1721298115
Siirrän sisällön seuraavan otsikon alle. ROCK1 ja Kalsiumjoni.
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