https://pubmed.ncbi.nlm.nih.gov/?term=ROCK1%2C+bone+mineralization&sort=date
6 results
Heraclenin promotes the osteogenic differentiation of bone marrow stromal cells by activating the RhoA/ROCK pathway.
Histol Histopathol. 2024 Aug;39(8):1065-1077. doi: 10.14670/HH-18-702. Epub 2024 Jan 3.
PMID: 38258549
BACKGROUND: Osteoporosis is a devastating skeletal disease, the pathogenesis of which is related to abnormal bone metabolism, featured by the imbalance between osteoblastic bone formation and osteoclastic bone resorption. ...Previously, the linear furanocouma …
Exosomal hsa_circ_0006859 is a potential biomarker for
postmenopausal osteoporosis and enhances adipogenic versus osteogenic
differentiation in human bone marrow mesenchymal stem cells by sponging miR-431-5p.
Stem Cell Res Ther. 2021 Mar 1;12(1):157. doi: 10.1186/s13287-021-02214-y.
PMID: 33648601
Free PMC article.
Alizarin red staining (ARS) was performed to evaluate the mineralization ability of human bone
marrow mesenchymal stem cells (hBMSCs). Oil Red O staining was
performed to evaluate the lipid droplet formation ability of hBMSCs.
...Hsa_circ_0006859 directly bound to m …
Low intensity pulsed ultrasound (LIPUS) maintains
osteogenic potency by the increased expression and stability of Nanog
through spleen tyrosine kinase (Syk) activation.
Cell Signal. 2019 Oct;62:109345. doi: 10.1016/j.cellsig.2019.109345. Epub 2019 Jun 19.
PMID: 31228531
Mesenchymal stem cells (MSCs) are a powerful tool for cell-based, clinical therapies like bone
regeneration. Therapeutic use of cell transplantation requires many
cells, however, the expansion process needed to produce large quantities
of cells reduces the differentiation …
Functions of Rho family of small GTPases and Rho-associated coiled-coil kinases in bone cells during differentiation and mineralization.
Biochim Biophys Acta Gen Subj. 2017 May;1861(5 Pt A):1009-1023. doi: 10.1016/j.bbagen.2017.02.005. Epub 2017 Feb 8.
PMID: 28188861
Review.
SCOPE OF THE REVIEW: Here, we focus on the action of RhoA and RhoA effectors, ROCK1 and ROCK2, in cells related to tissue mineralization:
mesenchymal stem cells, chondrocytes, preosteoblasts, osteoblasts,
osteocytes, lining cells and osteoclasts. ...Inhibition of Rh …
Novel role of zonula occludens-1: A tight junction
protein closely associated with the odontoblast differentiation of human
dental pulp cells.
Cell Biol Int. 2016 Jul;40(7):787-95. doi: 10.1002/cbin.10617. Epub 2016 May 11.
PMID: 27109589
RhoA/ROCK signaling suppresses hypertrophic chondrocyte differentiation.
J Biol Chem. 2004 Mar 26;279(13):13205-14. doi: 10.1074/jbc.M311427200. Epub 2004 Jan 15.
PMID: 14726536
Free article.
Coordinated proliferation and differentiation of growth plate
chondrocytes is required for normal growth and development of the
endochondral skeleton, but little is known about the intracellular
signal transduction pathways regulating these processes. We have
investigated the roles of the GTPase RhoA and its effector kinases
ROCK1/2 in hypertrophic chondrocyte differentiation. RhoA, ROCK1, and
ROCK2 are expressed throughout chondrogenic differentiation. RhoA
overexpression in chondrogenic ATDC5 cells results in increased
proliferation and a marked delay of hypertrophic differentiation, as
shown by decreased induction of alkaline phosphatase activity,
mineralization, and expression of the hypertrophic markers collagen X,
bone sialoprotein, and matrix metalloproteinase 13. These effects are
accompanied by activation of cyclin D1 transcription and repression of
the collagen X promoter by RhoA.
In contrast, inhibition of Rho/ROCK
signaling by the pharmacological inhibitor Y27632 inhibits chondrocyte
proliferation and accelerates hypertrophic differentiation.
Dominant-negative RhoA also inhibits induction of the cyclin D1 promoter
by parathyroid hormone-related peptide. Finally, Y27632 treatment
partially rescues the effects of RhoA overexpression. In summary, we
identify the RhoA/ROCK signaling pathway as a novel and important
regulator of chondrocyte proliferation and differentiation.
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