LYZ- geeni , lysozyymi, 1,4-beta-N-Acetylmuramidase C

 Kts UPDATE https://www.ajkd.org/article/S0272-6386(24)00679-6/fulltext

 

 Lysozyme geeni  GeneCards tietoa.  (Linkki ylhäällä: Haku  amyloidosis, LYZ mutaatiot. )

 LYZ, 12q15, 148 amino acids.

• GeneCards Symbol: LYZ ²
• Lysozyme ^{2 3 5}
• 1,4-Beta-N-Acetylmuramidase C ^{3 4}
• EC 3.2.1.17 ^{4 47}
• Lysozyme C ^{3 4}
• LZM ^{3 4}

• Lysozyme (Renal Amyloidosis) ²
• Renal Amyloidosis ²
• C-Type Lysozyme ³
• Lysozyme F1 ³
• AMYLD5 ³
• LYZF1 ³

• This gene encodes human lysozyme, whose natural substrate is the bacterial cell wall peptidoglycan (cleaving the beta[1-4]glycosidic linkages between N-acetylmuramic acid and N-acetylglucosamine). Lysozyme is one of the antimicrobial agents found in human milk, and is also present in spleen, lung, kidney, white blood cells, plasma, saliva, and tears. The protein has antibacterial activity against a number of bacterial species. Missense mutations in this gene have been identified in heritable renal amyloidosis. [provided by RefSeq, Oct 2014]

GeneCards Summary for LYZ Gene

LYZ (Lysozyme) is a Protein Coding gene. Diseases associated with LYZ include Amyloidosis, Hereditary Systemic 5 and Immunoglobulin Light Chain Amyloidosis. Among its related pathways are Innate Immune System and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include identical protein binding and lysozyme activity. An important paralog of this gene is SPACA3.

UniProtKB/Swiss-Prot Summary for LYZ Gene

Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. ( LYSC_HUMAN,P61626 )

Gene Families for LYZ Gene

HGNC:

• Lysozymes, c-type

The Human Protein Atlas (HPA):

• Disease related genes
• Enzymes
• Human disease related genes
• Plasma proteins
• Potential drug targets
• Predicted secreted proteins

Protein Domains for LYZ Gene

InterPro:

• Glyco_hydro_22
• Glyco_hydro_22_CS
• Lysozyme-like_dom_sf
• Glyco_hydro_22_lys

Blocks:

• Lysozyme signature

Suggested Antigen Peptide Sequences for LYZ Gene

GenScript: Design optimal peptide antigens:

• cDNA, FLJ92040, Homo sapiens lysozyme (renal amyloidosis) (LYZ), mRNA (B2R4C5_HUMAN)
• 1,4-beta-N-acetylmuramidase C (LYSC_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P61626

UniProtKB/Swiss-Prot:

LYSC_HUMAN :

• Belongs to the glycosyl hydrolase 22 family.

Family:

• Belongs to the glycosyl hydrolase 22 family.