https://www.genenames.org/data/genegroup/#!/group/409
ARMADILLO-toistoja sisältäviä alfa-solenoidisen hahmon omaavia, antiparalleelit alfa-helixit omaavia proteiineja on 43. MM. bewta-katgeniini. Linkki antaa 43 geeniä ja niiden koodaaman proteiinin nimi ja alis merkintöjä. GeneCards antaa geeninimellä laajemmat tiedot.
Armadillo repeat proteins Armadillo repeat is the name of a characteristic, repetitive amino acid sequence found in β-catenin and many other proteins, like α-importin, plakoglobin,or adenomatous polyposis coli (APC). Its name derives from the historical name of the β-catenin gene in the fruitfly Drosophila: where they were first discovered. Armadillo repeats are approximately 40 amino acids long and proteins that contain them usually have many tandemly repeated copies. These tandem repeats usually fold together to form a single, rigid protein domain called the armadillo (ARM) domain. Because ARM domains can consist of a variable number of repeats, they are a good example of solenoid protein domains. The best characterized example of armadillo domains is found in β-catenin. β-catenin is a protein involved in linking cadherin cell adhesion proteins to the cytoskeleton, but the Armadillo repeat is found in a wide range of proteins with other functions. This type of protein domain is important in transducing WNT signals during embryonic development. [Source: HGNC]
- GENEGARDS
THADA geenistä (2p21) ja sen koodaamasta THADA armadillo toistojaksot sisältävästä proteiinista.
https://www.genecards.org/cgi-bin/carddisp.pl?gene=THADA&keywords=THADA
- GENECARDS :
Beta-catenin1, Armadillo CTNNB1
https://www.genecards.org/cgi-bin/carddisp.pl?gene=CTNNB1&keywords=Beta,catenin
- GENECARDS
ANKAR, ankyrin and armadillo repeats containing protein; ankykriini- ja armadillo toistojaksot sisältävä proteiini
https://www.genecards.org/cgi-bin/carddisp.pl?gene=ANKAR&keywords=ANKAR
- GENECARDS
KPNB1 (Importin 1, subunit Beta) Tumaan kuljettavan importiinin alayksikkö beta, karyoferiini B.
https://www.genecards.org/cgi-bin/carddisp.pl?gene=KPNB1&keywords=%CE%B1-importin
Functions in nuclear protein import, either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (NLS) in cargo substrates, or by acting as autonomous nuclear transport receptor (PubMed:10228156, 11682607, 11891849, 19386897, 20818336, 24699649, 7615630, 9687515). Acting autonomously, serves itself as NLS receptor (PubMed:10228156, 11682607, 11891849, 19386897, 20818336, 24699649, 7615630, 9687515). Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism (PubMed:10228156, 11682607, 11891849, 19386897, 20818336, 24699649, 7615630, 9687515). At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin (PubMed:10228156, 11682607, 11891849, 19386897, 20818336, 24699649, 7615630, 9687515). The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (PubMed:10228156, 11682607, 11891849, 19386897, 24699649, 7615630, 9687515). Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5 (PubMed:11682607, 9687515). In association with IPO7, mediates the nuclear import of H1 histone (PubMed:10228156). In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones (By similarity). Imports MRTFA, SNAI1 and PRKCI into the nucleus (PubMed:11891849, 19386897, 20818336, 24699649). (
Inga kommentarer:
Skicka en kommentar