Katson uusimmat artikkelit tältä syksyltä:
Kommentti: PTEN indusoiva kinaasi1, PINK1 nousi mitokinonilla ja samoin NRF2. SAH modifioitu koeeläin. Siis on jokin menetelmä vaikuttaa PTEN-pitoisuuteen.
Expression of Concern for: "Mitophagy Reduces Oxidative Stress Via Keap1 (Kelch-Like Epichlorohydrin-Associated Protein 1)/Nrf2 (Nuclear Factor-E2-Related Factor 2)/PHB2 (Prohibitin 2) Pathway After Subarachnoid Hemorrhage in Rats".
Stroke. 2025 Oct 9. doi: 10.1161/STR.0000000000000504. Online ahead of print.
PMID: 41064914
No abstract available.
p66Shc silencing promotes aerobic glycolysis via signalling between the transcription factors NRF2 and HIF1-α.
Free Radic Biol Med. 2025 Oct 6;241:631-641. doi: 10.1016/j.freeradbiomed.2025.10.007. Online ahead of print.
PMID: 41061940
We previously found that silencing p66Shc, an adaptor protein
involved in apoptosis and reactive oxygen species (ROS) production,
enhances glycolysis, reduces mitochondrial ROS, and protects against
Abeta-induced toxicity. Here, we investigated whether p66Shc modulates
gly …
Vitamin K1 attenuates acetaminophen-induced ferroptotic
hepatic damage in mice via targeting keap1/Nrf2/HO-1 pathway.
Naunyn Schmiedebergs Arch Pharmacol. 2025 Oct 7. doi: 10.1007/s00210-025-04637-3. Online ahead of print.
PMID: 41055715
This study investigated the hepatoprotective effects of
vitamin K1(Vit K1) and its role in modulating ferroptosis via the Kelch-like ECH-associated protein 1 (Keap1), nuclear factor erythroid 2-related factor 2 (Nrf2) / heme oxygenase-1 (HO-1) antioxidant pat …
Prognostic and predictive implications of tumor suppressor gene alterations in non-small cell lung cancer.
Sci Rep. 2025 Oct 6;15(1):34807. doi: 10.1038/s41598-025-18662-y.
PMID: 41053251
Free PMC article.
L-arginine-loaded microneedle patch enhances diabetic
wound healing by regulating macrophage polarisation and mitochondrial
homeostasis.
Regen Biomater. 2025 Sep 1;12:rbaf092. doi: 10.1093/rb/rbaf092. eCollection 2025.
PMID: 41048975
Free PMC article.
Our findings demonstrate that L-Arg alleviated hydrogen
peroxide (H(2)O(2))-induced cellular damage through activation of the Kelch-like ECH-associated protein 1 (KEAP1)-nuclear factor erythroid 2-related factor 2 (Nrf2)-heme oxygenase-1 (HO-1) pathway, boost …
Decoding Sepsis: Unraveling Key Signaling Pathways for Targeted Therapies.
Research (Wash D C). 2025 Oct 1;8:0811. doi: 10.34133/research.0811. eCollection 2025.
PMID: 41041277
Free PMC article.
Review.
This article reviews major signaling pathways in sepsis,
such as those related to nuclear factor kappaB (NF-kappaB), Janus
kinase/signal transducer and activator of transcription (JAK/STAT),
Toll-like receptors (TLRs), mitogen-activated protein kinase (MAPK), hypoxia-induc …
Differential profiles of autophagy and Nrf2-mediated
antioxidant response in HBeAg-positive versus HBeAg-negative chronic
hepatitis B patients.
Front Microbiol. 2025 Sep 16;16:1637643. doi: 10.3389/fmicb.2025.1637643. eCollection 2025.
PMID: 41035887
Free PMC article.
Additionally, the Nrf2-Keap1 pathway (nuclear factor erythroid 2-related factor 2/Kelch-like ECH-associated protein
1) serves as a marker of antioxidant defense capacity, thereby allowing
an assessment of the contribution of oxidative stress to the progressio
…
Identification of antioxidant peptides from a bioactive peptide database PWDB of walnut family protein hydrolysates.
Food Chem. 2025 Sep 26;495(Pt 3):146548. doi: 10.1016/j.foodchem.2025.146548. Online ahead of print.
PMID: 41033032
Free article.
Molecular docking simulation revealed strong interactions between these peptides and key antioxidant receptors Kelch-like ECH-associated protein 1 (Keap1), Myeloperoxidase (MPO), and Xanthine Oxidase (XO), supporting their multi-target antioxidative potential …
Neurofilament light chain levels differentiate ischemic from inflammatory optic neuropathies.
Mult Scler Relat Disord. 2025 Sep 24;104:106771. doi: 10.1016/j.msard.2025.106771. Online ahead of print.
PMID: 41032997
Epstein-Barr Virus Hijacks Redox Signaling via
Glutathione Peroxidase 4 to Sustain Latency and Drive Gastric Cancer
Progression.
Antioxid Redox Signal. 2025 Sep 30. doi: 10.1177/15230864251382885. Online ahead of print.
PMID: 41027674
At the same time, EBV upregulates the expression of antioxidant enzyme GPX4 through the latent membrane protein 2A (LMP2A)/p62/Kelch-like ECH-associated protein 1(Keap1)/nuclear factor (erythroid-derived 2)-like 2 (NRF2) axis, eliminating excessive ROS …
Ganfule capsule alleviates AFB1-induced toxic liver
injury via inhibiting oxidative stress, inflammatory response, and
apoptosis.
Ecotoxicol Environ Saf. 2025 Sep 29;304:119125. doi: 10.1016/j.ecoenv.2025.119125. Online ahead of print.
PMID: 41027196
Free article.
In this study, cell and animal experiments have shown that GFL activates the Kelch like ECH associated protein 1 (Keap1)/nuclear factor erythroid 2-related factor 2 (Nrf2) antioxidant pathway in liver or hepatocytes. ...
Ulinastatin protects against cisplatin-induced ovarian damage via Nrf2/Keap1 pathway.
J Ovarian Res. 2025 Sep 29;18(1):207. doi: 10.1186/s13048-025-01760-w.
PMID: 41024007
Free PMC article.
Ursolic acid improves growth performance, intestinal
health, and antioxidant status in broilers by regulating lipid
metabolism and the KEAP1-NRF2 pathway.
J Anim Sci. 2025 Sep 29:skaf333. doi: 10.1093/jas/skaf333. Online ahead of print.
PMID: 41021452
The results showed that UA supplementation significantly enhanced growth and slaughter performance (P < 0.05), increased serum total protein (P < 0.05), and reduced serum triglycerides (P < 0.05). Untargeted metabolomics indicated that 200 mg/kg UA modulated lipid
…
1-Linoleoylglycerophosphocholine stimulates
UCP1-dependent thermogenesis and mitochondrial respiration to combat
obesity.
J Lipid Res. 2025 Sep 26:100914. doi: 10.1016/j.jlr.2025.100914. Online ahead of print.
PMID: 41016603
Free article.
Here, we provide evidence that
1-linoleoylglycerophosphocholine (1-LGPC) promotes adipocyte energy
expenditure by activating the Kelch-like ECH-associated protein 1-nuclear factor erythroid 2-related factor 2 (KEAP1-NRF2) axis. ...Elevated expression levels, …
LARP4B inhibits ferroptosis and accelerates the
progression of pancreatic cancer by activating WNK1-induced
NRF2/GCH1/BH4 pathway.
Integr Biol (Camb). 2025 Jan 8;17:zyaf019. doi: 10.1093/intbio/zyaf019.
PMID: 41014504
Mechanistically, LARP4B binds to mRNA of with-no-lysine
kinase 1 (WNK1) and promotes its stability, and WNK1 competitively binds
to the partial Kelch domain of Kelch-like ECH-associated protein 1 (Keap1) to promote the nuclear translocation of nuclear factor …
Genomic Analysis of Lumpy Skin Disease Virus from
Western and Central Africa Suggests a Distinct Sub-Lineage Within the
1.2 LSDV Cluster.
Pathogens. 2025 Sep 12;14(9):922. doi: 10.3390/pathogens14090922.
PMID: 41011822
Free PMC article.
Functional genomic analysis identified mutations in genes encoding ankyrin repeat Kelch-like proteins, and envelope proteins involved in immune evasion and viral virulence, raising concerns about vaccine effectiveness. ...
Betulinic Acid-Enriched Dillenia indica L. Bark Extract Attenuates UVB-Induced Skin Aging via KEAP1-Mediated Antioxidant Pathways.
Antioxidants (Basel). 2025 Sep 22;14(9):1144. doi: 10.3390/antiox14091144.
PMID: 41009048
Free PMC article.
Molecular docking and molecular dynamics simulations revealed that BA binds stably to Kelch-like ECH-associated protein 1 (KEAP1), suggesting activation of the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway. ...
Thymol Preserves Spermatogenesis and Androgen Production
in Cisplatin-Induced Testicular Toxicity by Modulating Ferritinophagy,
Oxidative Stress, and the Keap1/Nrf2/HO-1 Pathway.
Biomolecules. 2025 Sep 3;15(9):1277. doi: 10.3390/biom15091277.
PMID: 41008584
Free PMC article.
AI cancer driver mutation predictions are valid in real-world data.
Nat Commun. 2025 Sep 26;16(1):8509. doi: 10.1038/s41467-025-63461-8.
PMID: 41006257
Free PMC article.
Artificial intelligence (AI) has delivered significant advances in protein
structure prediction, but its utility for identifying cancer drivers is
less explored. ...For re-identifying known drivers, methods
incorporating protein structure or functional genomic data …
Sofalcone inhibits osteoclastogenesis through Keap1/Nrf2
signaling activation and mitigates ovariectomy-induced bone loss.
Int Immunopharmacol. 2025 Sep 25;166:115589. doi: 10.1016/j.intimp.2025.115589. Online ahead of print.
PMID: 41005145
Our in vitro studies reveal that SFC inhibits
osteoclastogenesis and reduces osteoclastic bone resorption. It achieves
this by enhancing the Kelch-like ECH-associated protein 1 (Keap1)/nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway, whic …
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