ASB proteiineista vuoden 2018 artikkeli

 

Artikkeli proteiinien ubikitinaation ja proteosomaalisen degradaation ja säätelyn alalta.

VIVEK VISHNU, PRITI TALWAR etal. 2018 .

Multifaceted Roles of ASB protein and its pathological significance

Tätä tekstiä en saa esiin netistä kokonaisuudessaan.  Otan avainsanoja  kutienkin ja  geenitietoa sekä jonkin muun saman aiheen artikkelin. PubMedin uutiset  10 kpl  hakusana ilmaisee ASB  geenin koodaamanproteiinin nimen: Ankyrin repeat SOCS Box containing protein 

Avainsanoja

PTM, Post-translationa modification

ASB, Ankyrin repeat SOCS Box

ANK , ankyrin repeat

SOCS, Suppressor of cytokine signalling

RING, Really interesting new gene

ECS, Elongin- Cullin-SOCS

SRS, Substrate Recognition Subunit

Elongin B/C, adaptor

ATRA, all-trans-Retinoic acid

ASB genes belong to RING ligase subclass CLR

ECS type,EloBC-Cullin-SOCS

CLR = CUL-RING- Ligases

(There is 7 CUL in humn genes: Cul1, Cul2,.Cul3,Cul4a, Cul4b, Cul5, Cul7,Each binds to a specific adaptor and motifs with in SRS)

RBX = Ring Box Motif

Cullin and RBX : Scaffold protins

SCF, Specificity Factor for a family of ubiquitinligases composed of Skp1,Rbx1,Cullin 1 and Fbox protein.

VHL type, von Hippel Lindau

POAG, Primary open angle glaucoma

HIF, Hypoxia inducible factor

TNF-alfa, RII-tumor necrosis factor alpha receptor 2

NF-kB,Nuclear factor-kB

ASB perheen geenit: GeneCards, haku.

GeneCards tieto 

ASB1, Ankyrin Repeat And SOCS Box Containing 1

https://www.genecards.org/cgi-bin/carddisp.pl?gene=ASB1&keywords=ASB1

Tuumorisuppressori: https://pubmed.ncbi.nlm.nih.gov/39113857/

Mitokondrian kristan rakenne. MICOS complexi. CMV tmuuntaa mitok. kristaa, jossa on

KTS enemmän tietoa mitokondrian kalvoproteiineista ATPsynteesi paikka. https://www.genecards.org/cgi-bin/carddisp.pl?gene=CHCHD3&keywords=CHCHD3

ASB2

https://www.genecards.org/Search/Keyword?queryString=ASB2

ASB3

ASB4

ASB5

ASB6

ASB7

ASB8

ASB9

ASB10

ASB11

ASB12

ASB13

ASB14

ASB15

ASB16

ASB17

ASB18 Päivän lukuaihe otsikon artikkeli. 27.10.2025

HAKU: .Uuta artikkelia löytyy 2024 2025

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1

Correspondence to the editorial on "Targeting the ASB3-CPT1A axis-a new player in combating metabolic dysfunction-associated steatotic liver disease (CHM-2025-1013)".

Lin Y, Yang D, Wu Z, Guan M, Song C. Clin Mol Hepatol. 2025 Sep 29. doi: 10.3350/cmh.2025.1086. Online ahead of print. PMID: 41022378 Free article. No abstract available.

2

Correspondence to the editorial "ASB3 degrades the gateway to β-oxidation: on Hepatocytic ASB3 deficiency alleviates MASLD by decreasing ubiquitin-mediated CPT1A".

Yang D, Lin Y, Song C, Guan M. Clin Mol Hepatol. 2025 Sep 29. doi: 10.3350/cmh.2025.1100. Online ahead of print. PMID: 41022377 Free article. No abstract available.

3

Targeting the ASB3-CPT1A axis-a new player in combating metabolic dysfunction-associated steatotic liver disease.

Yang Y, Yang Y, Lu Y. Clin Mol Hepatol. 2025 Sep 15. doi: 10.3350/cmh.2025.1013. Online ahead of print. PMID: 40947606 Free article. No abstract available.

4

Hepatocytic ankyrin repeat and SOCS box protein 3 deficiency alleviates metabolic dysfunction-associated steatotic liver disease by decreasing ubiquitin-mediated carnitine palmitoyl transferase 1A.

Lin Y, Hou W, Ge M, Wu Z, Huang L, Liu H, Zhang W, Deng X, Wang L, Guan M, Song C, Wang Z, Yang D. Clin Mol Hepatol. 2025 Oct;31(4):1333-1354. doi: 10.3350/cmh.2024.1041. Epub 2025 Aug 8. PMID: 40776473 Free PMC article.

BACKGROUND/AIMS: Excessive lipid accumulation in hepatocytes is a critical cause of metabolic dysfunction-associated steatotic liver disease (MASLD) progression. Ankyrin repeat and SOCS box protein 3 (ASB3) is an E3 ubiquitin ligase that mediate …

5

ASB3 ablation has no detectable effects on spermatogenesis and fertility in male mice.

Xu C, Qiu X, Zheng A, Pu Y, Wu T, Ding J, Zheng B. PeerJ. 2025 Jul 31;13:e19738. doi: 10.7717/peerj.19738. eCollection 2025. PMID: 40755808 Free PMC article.

BACKGROUND: As a member of the Ankyrin repeat and SOCS box (Asb) family, the Asb3 is enriched in the testes and highly conserved in multiple species. ...

6

The E3 ligase ASB3 downregulates antiviral innate immunity by targeting MAVS for ubiquitin-proteasomal degradation.

Cheng M, Lu Y, Wang J, Wang H, Sun Y, Zhao W, Wang J, Shi C, Luo J, Gao M, Yu T, Wang J, Guan J, Wang N, Yang W, Jiang Y, Huang H, Yang G, Cao X, Yang D, Wang C, Zeng Y. Cell Death Differ. 2024 Dec;31(12):1746-1760. doi: 10.1038/s41418-024-01376-5. Epub 2024 Sep 12. PMID: 39266719

E3 ubiquitin ligases are very important for regulating antiviral immunity during viral infection. Here, we discovered that Ankyrin repeat and SOCS box-containing protein 3 (ASB3), an E3 ligase, are upregulated in the presence of RNA viruses, par …

7

The Roles of Obesity and ASB4 in Preeclampsia Pathogenesis.

Wang Y, Ssengonzi R, Townley-Tilson WHD, Kayashima Y, Maeda-Smithies N, Li F. Int J Mol Sci. 2024 Aug 20;25(16):9017. doi: 10.3390/ijms25169017. PMID: 39201703 Free PMC article. Review.

However, the precise mechanisms by which obesity influences preeclampsia are unclear. Ankyrin repeat and SOCS Box Containing protein 4 (ASB4) is an E3 ubiquitin ligase that can promote the degradation of a wide range of target proteins. . …

8

ASB3 expression aggravates inflammatory bowel disease by targeting TRAF6 protein stability and affecting the intestinal microbiota.

Cheng M, Xu B, Sun Y, Wang J, Lu Y, Shi C, Pan T, Zhao W, Li X, Song X, Wang J, Wang N, Yang W, Jiang Y, Huang H, Yang G, Zeng Y, Yang D, Wang C, Cao X. mBio. 2024 Sep 11;15(9):e0204324. doi: 10.1128/mbio.02043-24. Epub 2024 Aug 20. PMID: 39162488 Free PMC article.

E3 ubiquitin ligase (E3) plays a vital role in regulating inflammatory responses by mediating ubiquitination. Previous studies have shown that ankyrin repeat and SOCS box-containing protein 3 (ASB3) is involved in immunomodulatory functions asso …

9

ASB1 inhibits prostate cancer progression by destabilizing CHCHD3 via K48-linked ubiquitination.

Zhao C, Xu Z, Que H, Zhang K, Wang F, Tan R, Fan C. Am J Cancer Res. 2024 Jul 15;14(7):3404-3418. doi: 10.62347/FEIZ7492. eCollection 2024. PMID: 39113857 Free PMC article.

Prostate cancer is a major contributor to male mortality worldwide. In this study, we revealed that Ankyrin Repeat and SOCS Box Containing 1 (ASB1) expression was significantly decreased in prostate cancer tissues, correlating strongly with poor patien …

10

Genome-wide mapping of the binding sites of myocyte enhancer factor 2A in chicken primary myoblasts.

Wang X, Zhang J, Su J, Huang T, Lian L, Nie Q, Zhang X, Li J, Wang Y. Poult Sci. 2024 Oct;103(10):104097. doi: 10.1016/j.psj.2024.104097. Epub 2024 Jul 14. PMID: 39094502 Free PMC article.

Moreover, a comparison of the MEF2A target genes identified in chicken primary myoblasts with those in mouse C2C12 cells revealed 388 target genes are conserved across species, 1515 target genes are chicken specific. Among these conserved genes, ankyrin repeat and …

https://doi.org/10.1007/s11515-018-1506-2.

LÄHDETIETOA TARVITAAN LISÄÄ  CUL5 scaffold proteiinita varsinkin. 

CLR5 :Abstract

Cullin-RING ligase 5 (CRL5) is a multi-protein complex and consists of a scaffold protien cullin 5, a RING protein RBX2 (also known as ROC2 or SAG), adaptor proteins Elongin B/C, and a substrate receptor protein SOCS. Through targeting a variety of substrates for proteasomal degradation or modulating various protein-protein interactions, CRL5 is involved in regulation of many biological processes, such as cytokine signal transduction, inflammation, viral infection, and oncogenesis. As many substrates of CRL5 are well-known oncoproteins or tumor suppressors, abnormal regulation of CRL5 is commonly found in human cancers. In this review, we first briefly introduce each of CRL5 components, and then discuss the biological processes regulated by four members of SOCS-box-containing substrate receptor family through substrate degradation. We next describe how CRL5 is hijacked by a variety of viral proteins to degrade host anti-viral proteins, which facilitates virus infection. We further discuss the regulation of CUL5 and its various roles in human cancers, acting as either a tumor suppressor or an oncoprotein in a context-dependent manner. Finally, we propose novel insights for future perspectives on the validation of cullin5 and other CRL5 components as potential targets, and possible targeting strategies to discover CRL5 inhibitors for anti-cancer and anti-virus therapies.