https://www.researchgate.net/publication/319878924_Association_of_SIRT-1_T_helper_17-associated_gene_and_Antimicrobial_Peptides_gene_in_Inflammatory_Bowel_Disease_Patients
The aim of this study was to assess the expression of Th17-associated
gene, AMPs genes and SIRT-1 protein in patients with inflammatory bowel
disease (IBD).
Material and Methods: We studied a group of 20 IBD patients, together
with 20 subjects served as controls. Colonoscopy, terminal ileoscopy,
and colonoscopic biopsy were performed for histopathology diagnosis, and
quantitative gene expression of Th17-associated gene, CAMP, Elafin and
SLPI by real-time PCR. SIRT-1 protein level expression was assessed by
western blot.
Results: The expression of the four studied genes—elafin, SLPI, CAMP and
Th17-associated gene—by relative quantification was higher in the
patient group than in the control group. A statistically significant
positive correlation was found between SLPI and elafin in the patient
group (r= 0.8325 P
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