FILIP1 like (3q12.1), GIP90, GIP130

https://www.ncbi.nlm.nih.gov/gene/11259

Also known as

DOC1; DOC-1; GIP90; GIP130

Expression

Ubiquitous expression in gall bladder (RPKM 44.5), urinary bladder (RPKM 29.8) and 23 other tissues See more

Preferred Names

filamin A-interacting protein 1-like

Names

130 kDa GPBP-interacting protein

90 kDa GPBP-interacting protein

protein down-regulated in ovarian cancer 1 (DOC1, DOC-1)

 Isoform-3

Conserved Domains (2) summary

pfam09727
Location:66 → 248

CortBP2; Cortactin-binding protein-2

pfam14662
Location:309 → 481

KASH_CCD; Coiled-coil region of CCDC155 or KASH

 Isoform 4

Conserved Domains (4) summary

pfam00261
Location:3 → 260

Tropomyosin; Tropomyosin

pfam12001
Location:41 → 110

DUF3496; Domain of unknown function (DUF3496)

cl03075
Location:196 → 247

GrpE; nucleotide exchange factor GrpE

cl19219
Location:123 → 221

DUF342; Protein of unknown function (DUF342)

 Isoform 5

Conserved Domains (2) summary

pfam06160
Location:16 → 537

EzrA; Septation ring formation regulator, EzrA

cl19219
Location:171 → 241

DUF342; Protein of unknown function (DUF342)

 Isoform 2

Conserved Domains (1) summary

cl25732
Location:18 → 491

SMC_N; RecF/RecN/SMC N terminal domain

 

RecF/RecN/SMC N terminal domain

This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.

 Isoform 1

Conserved Domains (2) summary

pfam09727
Location:66 → 248

CortBP2; Cortactin-binding protein-2

pfam14662
Location:309 → 481

KASH_CCD; Coiled-coil region of CCDC155 or KASH

Related articles in PubMed

1. Filamin A interacting protein 1-like expression inhibits progression in colorectal cancer. Park YL, et al. Oncotarget, 2016 Nov 1. PMID 27750216, Free PMC Article
2. Down-regulation of Filamin A interacting protein 1-like Is associated with promoter methylation and an invasive phenotype in breast, colon, lung and pancreatic cancers [corrected]. Kwon M, et al. PLoS One, 2013. PMID 24340050, Free PMC Article
3. Filamin A interacting protein 1-like inhibits WNT signaling and MMP expression to suppress cancer cell invasion and metastasis. Kwon M, et al. Int J Cancer, 2014 Jul 1. PMID 24327474, Free PMC Article
4. CpG island hypermethylation frequently silences FILIP1L isoform 2 expression in prostate cancer. Desotelle J, et al. J Urol, 2013 Jan. PMID 23174249, Free PMC Article
5. Sensitivity to TOP2 targeting chemotherapeutics is regulated by Oct1 and FILIP1L. Lu H, et al. PLoS One, 2012. PMID 22900064, Free PMC Article

See all (26) citations in PubMed