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1. Expression and Clinical Significance of Elafin in Inflammatory Bowel Disease. Zhang W, et al. Inflamm Bowel Dis, 2017 Dec. PMID 29084078
2. Recombinant human elafin promotes alveologenesis in newborn mice exposed to chronic hyperoxia. Han W, et al. Int J Biochem Cell Biol, 2017 Nov. PMID 28802561
3. Anti-inflammatory Elafin in human fetal membranes. Stalberg C, et al. J Perinat Med, 2017 Feb 1. PMID 27580179
4. Protective effects of elafin against adult asthma. Tsai YS, et al. Allergy Asthma Proc, 2016 Mar-Apr. PMID 26932165
5. Elafin is downregulated during breast and ovarian tumorigenesis but its residual expression predicts recurrence. Caruso JA, et al. Breast Cancer Res, 2014. PMID 25551582, Free PMC Article

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1. Elafin decreased in active patients with inflammatory bowel disease and was negatively correlated with disease activity, suggesting that elafin may play a protective role
2. Plasma Neutrophil Elastase and Elafin as Prognostic Biomarker for Acute Respiratory Distress Syndrome
3. UV phototoxicity-induced pre-elafin inside keratinocytes prior to cornified envelope formation could be involved in UV-induced keratinocyte apoptosis via cystatin-A downregulation resulting in pro-caspase-3 activation.
4. Recombinant human elafin promotes alveologenesis in newborn mice exposed to chronic hyperoxia
5. significantly higher expression in preterm prelabor ruptured fetal membranes than in membranes from term birth
6. Our study revealed that high elafin levels identified in smoking- and asthma-related microarray data sets and an epidemiologic study significantly reduced the risk of asthma.
7. The expression of elafin in fallopian tubes of ectopic pregnancies is reduced.
8. The elevations in cervical elafin and SLPI expression in the women with preterm delivery might reflect the local response to the pathogen invasion into the cervix preceding preterm labor.
9. PI3 expression was downregulated in 24% of DCIS and 83% of invasive breast tumors. PI3 was also downregulated in 33% of ovarian cystadenomas, 43% of borderline ovarian tumors, and 86% of invasive ovarian carcinomas.
10. The imbalance between neutrophil elastase and its inhibitors, such as elafin, presents an important therapeutic target in breast cancer.

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