FILIP1 (6q14.1). FILIP tekee interaktion filamiini-A;n kanssa

 https://www.ncbi.nlm.nih.gov/gene/27145

Filamiini A :n kanssa interaktion tekevä proteiini  on FILIP ja se edistää FilamiiniA:n hajoittamista ja säädellee kortikaalisen neuronin migraatiota ja dendriittihaarakkeiden morfologiaa.  Jos hiireltä puuttuu tämän geenin funktionaalinen kopio ilmenee alentunutta dendriittihaarakkeiden pituutta ja muuntunutta exkitatorista signalointia.

Also known as

FILIP

Summary

This gene encodes a filamin A binding protein. The encoded protein promotes the degradation of filamin A and may regulate cortical neuron migration and dendritic spine morphology. Mice lacking a functional copy of this gene exhibit reduced dendritic spine length and altered excitatory signaling. [provided by RefSeq, Oct 2016]

Expression

Biased expression in heart (RPKM 16.2), esophagus (RPKM 4.3) and 12 other tissues See 

Preferred Names

filamin-A-interacting protein 1

Conserved Domains (4) summary

PRK03918
Location:208 → 741

PRK03918; chromosome segregation protein; Provisional

pfam06156
Location:389 → 461

DUF972; Protein of unknown function (DUF972)

pfam09727
Location:77 → 258

CortBP2; Cortactin-binding protein-2

cl23720
Location:428 → 532

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

 

Related articles in PubMed

1. Filamin A-interacting protein (FILIP) regulates cortical cell migration out of the ventricular zone. Nagano T, et al. Nat Cell Biol, 2002 Jul. PMID 12055638
2. RhoD regulates cytoskeletal dynamics via the actin nucleation-promoting factor WASp homologue associated with actin Golgi membranes and microtubules. Gad AK, et al. Mol Biol Cell, 2012 Dec. PMID 23087206, Free PMC Article
3. Promotion of heat shock factor Hsf1 degradation via adaptor protein filamin A-interacting protein 1-like (FILIP-1L). Hu Y, et al. J Biol Chem, 2011 Sep 9. PMID 21784850, Free PMC Article
4. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. Nagase T, et al. DNA Res, 1999 Oct 29. PMID 10574462
5. Differential effects of Tat proteins derived from HIV-1 subtypes B and recombinant CRF02_AG on human brain microvascular endothelial cells: implications for blood-brain barrier dysfunction. Woollard SM, et al. J Cereb Blood Flow Metab, 2014 Jun. PMID 24667918, Free PMC Article