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fredag 30 november 2018

COL2A1 (12q13.11) rusto ja lasiaiskollageeni

https://www.ncbi.nlm.nih.gov/gene/1280
 Tämä COL2A1- geeni koodaa tyypin II kollageenia, joka on fibrillaarista ja muodostaa rustoa ja silmän lasiasita. tässä rusto ja lasiaiskollageenin  peptidisekvenssissä huomaa enemmän BCFA ( haaroittuneita aminohappoja) kuin  tuossa jänne- ja luu kollageenissa edellä.  Siis viittaisi esim palkohedelmäravinnon ja kalaravinnon etuihin.  ruston ja silmän konsistenssin suhteen. On myös alaniinia (a)  runsaasti, eli ollut liikuntaa, jossa hiiliketjut  ovat saaneet  fundamentaalisti   aminoryhmänsä  .
Also known as
AOM; ANFH; SEDC; STL1; COL11A3
Summary
This gene encodes the alpha-1 chain of type II collagen, a fibrillar collagen found in cartilage and the vitreous humor of the eye. Mutations in this gene are associated with achondrogenesis, chondrodysplasia, early onset familial osteoarthritis, SED congenita, Langer-Saldino achondrogenesis, Kniest dysplasia, Stickler syndrome type I, and spondyloepimetaphyseal dysplasia Strudwick type. In addition, defects in processing chondrocalcin, a calcium binding protein that is the C-propeptide of this collagen molecule, are also associated with chondrodysplasia. There are two transcripts identified for this gene. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs mouse all
Preferred Names
collagen alpha-1(II) chain
Names
alpha-1 type II collagen
arthroophthalmopathy, progressive (Stickler syndrome)
cartilage collagen
chondrocalcin
collagen II, alpha-1 polypeptide
collagen, type II, alpha 1
Structure, sequence,   https://www.ncbi.nlm.nih.gov/protein/NP_001835.3
 
ORIGIN      
        1 mirlgapqtl vlltllvaav lrcqgqdvqe agscvqdgqr yndkdvwkpe pcricvcdtg
       61 tvlcddiice dvkdclspei pfgeccpicp tdlatasgqp gpkgqkgepg dikdivgpkg
      121 ppgpqgpage qgprgdrgdk gekgapgprg rdgepgtpgn pgppgppgpp gppglggnfa
      181 aqmaggfdek aggaqlgvmq gpmgpmgprg ppgpagapgp qgfqgnpgep gepgvsgpmg
      241 prgppgppgk pgddgeagkp gkagergppg pqgargfpgt pglpgvkghr gypgldgakg
      301 eagapgvkge sgspgengsp gpmgprglpg ergrtgpaga agargndgqp gpagppgpvg
      361 paggpgfpga pgakgeagpt gargpegaqg prgepgtpgs pgpagasgnp gtdgipgakg
      421 sagapgiaga pgfpgprgpp gpqgatgplg pkgqtgepgi agfkgeqgpk gepgpagpqg
      481 apgpageegk rgargepggv gpigppgerg apgnrgfpgq dglagpkgap gergpsglag
      541 pkgangdpgr pgepglpgar gltgrpgdag pqgkvgpsga pgedgrpgpp gpqgargqpg
      601 vmgfpgpkga ngepgkagek glpgapglrg lpgkdgetga agppgpagpa gergeqgapg
      661 psgfqglpgp pgppgeggkp gdqgvpgeag apglvgprge rgfpgergsp gaqglqgprg
      721 lpgtpgtdgp kgasgpagpp gaqgppglqg mpgergaagi agpkgdrgdv gekgpegapg
      781 kdggrgltgp igppgpagan gekgevgppg pagsagarga pgergetgpp gpagfagppg
      841 adgqpgakge qgeagqkgda gapgpqgpsg apgpqgptgv tgpkgargaq gppgatgfpg
      901 aagrvgppgs ngnpgppgpp gpsgkdgpkg argdsgppgr agepglqgpa gppgekgepg
      961 ddgpsgaegp pgpqglagqr givglpgqrg ergfpglpgp sgepgkqgap gasgdrgppg
     1021 pvgppgltgp agepgregsp gadgppgrdg aagvkgdrge tgavgapgap gppgspgpag
     1081 ptgkqgdrge agaqgpmgps gpagargiqg pqgprgdkge agepgerglk ghrgftglqg
     1141 lpgppgpsgd qgasgpagps gprgppgpvg psgkdgangi pgpigppgpr grsgetgpag
     1201 ppgnpgppgp pgppgpgidm safaglgpre kgpdplqymr adqaagglrq hdaevdatlk
     1261 slnnqiesir spegsrknpa rtcrdlklch pewksgdywi dpnqgctlda mkvfcnmetg
     1321 etcvypnpan vpkknwwssk skekkhiwfg etinggfhfs ygddnlapnt anvqmtflrl
     1381 lstegsqnit yhcknsiayl deaagnlkka lliqgsndve iraegnsrft ytalkdgctk
     1441 htgkwgktvi eyrsqktsrl piidiapmdi ggpeqefgvd igpvcfl
//
 
Conserved Domains (3) summary
pfam01391
Location:801860
Collagen; Collagen triple helix repeat (20 copies)
pfam00093
Location:3489
VWC; von Willebrand factor type C domain
pfam01410
Location:12541486
COLFI; Fibrillar collagen C-terminal domain
 

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