Tähän proteiiniin PTX3 liittyy paljon artikkeleita PubMed lähteessä. Tässä on vain rakenteeseen liittyvät referaatit ja sekvenssi. Otgan myös käytetyt nimet esiin ja konservoidun domeenin.
(Huom. PTX3:n synteetinen derivaatta pan-FGF2 trap https://pubs.acs.org/doi/10.1021/acs.jmedchem.5b02021
- Also known as
- TSG-14; TNFAIP5
- Summary
- This gene encodes a member of the pentraxin protein family. The expression of this protein is induced by inflammatory cytokines in response to inflammatory stimuli in several mesenchymal and epithelial cell types, particularly endothelial cells and mononuclear phagocytes. The protein promotes fibrocyte differentiation and is involved in regulating inflammation and complement activation. It also plays a role in angiogenesis and tissue remodeling. The protein serves as a biomarker for several inflammatory conditions. [provided by RefSeq, Jun 2016]
- Expression
- Biased expression in bone marrow (RPKM 32.2), appendix (RPKM 24.8) and 6 other tissues
- Preferred Names
- pentraxin-related protein PTX3
- Names
- TNF alpha-induced protein 5
- long pentraxin 3
- tumor necrosis factor alpha-induced protein 5
- tumor necrosis factor-inducible gene 14 protein
- tumor necrosis factor-inducible protein TSG-14
- Conserved Domains (2) summary
-
- smart00159
Location:175 → 381 - PTX; Pentraxin / C-reactive protein / pentaxin family
- cl23844
Location:81 → 167 - Ble; Predicted trehalose synthase [Carbohydrate transport and metabolism]
- smart00159
pentraxin-related protein PTX3 precursor [Homo sapiens]
NCBI Reference Sequence: NP_002843.2
LOCUS NP_002843 381 aa linear PRI 21-OCT-2018 DEFINITION pentraxin-related protein PTX3 precursor [Homo sapiens]. ACCESSION NP_002843 VERSION NP_002843.2 DBSOURCE REFSEQ: accession NM_002852.3 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (residues 1 to 381) AUTHORS Zhang CY, Han HD, Wang SY, Huang SR and Deng BQ. TITLE Pentraxin-3 in Thrombolytic Therapy for Acute Ischemic Stroke: No Relation with Curative Effect and Prognosis JOURNAL Med. Sci. Monit. 24, 4427-4432 (2018) PUBMED 29949524 REMARK GeneRIF: PTX3 is not suitable to serve as an indicator of thrombolytic efficacy and had no association with long-term prognosis in stroke patients receiving thrombolytic therapy. Publication Status: Online-Only REFERENCE 2 (residues 1 to 381) AUTHORS Takashi Y, Koga M, Matsuzawa Y, Saito J, Omura M and Nishikawa T. TITLE Circulating pentraxin 3 is positively associated with chronic hyperglycemia but negatively associated with plasma aldosterone concentration JOURNAL PLoS ONE 13 (5), e0196526 (2018) PUBMED 29715313 REMARK GeneRIF: PTX3 is positively regulated by chronic hyperglycemia but negatively regulated by aldosterone Publication Status: Online-Only REFERENCE 3 (residues 1 to 381) AUTHORS Mou P, Chen Z, Jiang L, Cheng J and Wei R. TITLE PTX3: A Potential Biomarker in Thyroid Associated Ophthalmopathy JOURNAL Biomed Res Int 2018, 5961974 (2018) PUBMED 29675428 REMARK GeneRIF: Patients with TAO showed increased presence of PTX3 in orbital tissue and serum. Publication Status: Online-Only REFERENCE 4 (residues 1 to 381) AUTHORS Scimeca M, Salustri A, Bonanno E, Nardozi D, Rao C, Piccirilli E, Feola M, Tancredi V, Rinaldi A, Iolascon G, Orlandi A, Gasbarra E, Maffulli N, Brandi ML and Tarantino U. TITLE Impairment of PTX3 expression in osteoblasts: a key element for osteoporosis JOURNAL Cell Death Dis 8 (10), e3125 (2017) PUBMED 29022895 REMARK GeneRIF: treatment of human osteoblast primary cultures derived from young patients with anti-PTX3 antibody, osteoblasts lost the morphological and molecular features typical of mature osteoblasts, acquiring fibroblast-like shape and highly decreasing nuclear factor kappa-B ligand (RANKL) and RUNX2 expression. Publication Status: Online-Only REFERENCE 5 (residues 1 to 381) AUTHORS Narciso-Schiavon JL, Pereira JG, Silva TE, Bansho ETO, Morato EF, Pinheiro JT, Muraro-Wildner L, Bazzo ML, Dantas-Correa EB and Schiavon LL. TITLE Circulating levels of pentraxin-3 (PTX3) in patients with liver cirrhosis JOURNAL Ann Hepatol 16 (5), 780-787 (2017) PUBMED 28809733 REMARK GeneRIF: Serum PTX3 is related to the severity of autoimmune hepatitis, the presence of acute-on-chronic liver failure and 90-day mortality. REFERENCE 6 (residues 1 to 381) AUTHORS Alles VV, Bottazzi B, Peri G, Golay J, Introna M and Mantovani A. TITLE Inducible expression of PTX3, a new member of the pentraxin family, in human mononuclear phagocytes JOURNAL Blood 84 (10), 3483-3493 (1994) PUBMED 7949102 REFERENCE 7 (residues 1 to 381) AUTHORS Lee GW, Goodman AR, Lee TH and Vilcek J. TITLE Relationship of TSG-14 protein to the pentraxin family of major acute phase proteins JOURNAL J. Immunol. 153 (8), 3700-3707 (1994) PUBMED 7523502 REFERENCE 8 (residues 1 to 381) AUTHORS Lee GW, Lee TH and Vilcek J. TITLE TSG-14, a tumor necrosis factor- and IL-1-inducible protein, is a novel member of the pentaxin family of acute phase proteins JOURNAL J. Immunol. 150 (5), 1804-1812 (1993) PUBMED 7679696 REFERENCE 9 (residues 1 to 381) AUTHORS Breviario F, d'Aniello EM, Golay J, Peri G, Bottazzi B, Bairoch A, Saccone S, Marzella R, Predazzi V, Rocchi M et al. TITLE Interleukin-1-inducible genes in endothelial cells. Cloning of a new gene related to C-reactive protein and serum amyloid P component JOURNAL J. Biol. Chem. 267 (31), 22190-22197 (1992) PUBMED 1429570 REFERENCE 10 (residues 1 to 381) AUTHORS Lee TH, Wisniewski HG and Vilcek J. TITLE A novel secretory tumor necrosis factor-inducible protein (TSG-6) is a member of the family of hyaluronate binding proteins, closely related to the adhesion receptor CD44 JOURNAL J. Cell Biol. 116 (2), 545-557 (1992) PUBMED 1730767 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA716533.1, BC039733.1 and BQ010272.1. This sequence is a reference standard in the RefSeqGene project. On Feb 16, 2008 this sequence version replaced NP_002843.1. Summary: This gene encodes a member of the pentraxin protein family. The expression of this protein is induced by inflammatory cytokines in response to inflammatory stimuli in several mesenchymal and epithelial cell types, particularly endothelial cells and mononuclear phagocytes. The protein promotes fibrocyte differentiation and is involved in regulating inflammation and complement activation. It also plays a role in angiogenesis and tissue remodeling. The protein serves as a biomarker for several inflammatory conditions. [provided by RefSeq, Jun 2016]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK312705.1, BC039733.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## FEATURES Location/Qualifiers source 1..381 /organism="Homo sapiens" /db_xref="taxon:9606" /chromosome="3" /map="3q25.32" Protein 1..381 /product="pentraxin-related protein PTX3 precursor" /note="pentraxin-related protein PTX3; tumor necrosis factor-inducible protein TSG-14; TNF alpha-induced protein 5; tumor necrosis factor alpha-induced protein 5; tumor necrosis factor-inducible gene 14 protein; long pentraxin 3" /calculated_mol_wt=40121 sig_peptide 1..17 /inference="COORDINATES: ab initio prediction:SignalP:4.0" /calculated_mol_wt=1872 mat_peptide 18..381 /product="Pentraxin-related protein PTX3" /experiment="experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (P26022.3)" /calculated_mol_wt=40121 Region <81 ..="">167 /region_name="Ble" /note="Predicted trehalose synthase [Carbohydrate transport and metabolism]; cl23844" /db_xref="CDD:305001" Region 175..381 /region_name="PTX" /note="Pentraxin / C-reactive protein / pentaxin family; smart00159" /db_xref="CDD:128463" Site order(234,313,315,324,327) /site_type="other" /note="calcium mediated ligand binding site" /db_xref="CDD:238086" Site order(275,292,332,380) /site_type="other" /note="intermolecular salt bridges" /db_xref="CDD:238086" CDS 1..381 /gene="PTX3" /gene_synonym="TNFAIP5; TSG-14" /coded_by="NM_002852.3:144..1289" /db_xref="CCDS:CCDS3180.1" /db_xref="GeneID:5806" /db_xref="HGNC:HGNC:9692" /db_xref="MIM:602492" ORIGIN 1 mhllailfca lwsavlaens ddydlmyvnl dneidnglhp tedptpcacg qehsewdklf 61 imlensqmre rmllqatddv lrgelqrlre elgrlaesla rpcapgapae arltsaldel 121 lqatrdagrr larmegaeaq rpeeagrala avleelrqtr adlhavqgwa arswlpagce 181 tailfpmrsk kifgsvhpvr pmrlesfsac iwvkatdvln ktilfsygtk rnpyeiqlyl 241 syqsivfvvg geenklvaea mvslgrwthl cgtwnseegl tslwvngela attvematgh 301 ivpeggilqi gqekngccvg ggfdetlafs grltgfniwd svlsneeire tggaeschir 361 gnivgwgvte iqphggaqyv s //
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